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Table 1 Metabolic phenotyping of control and DEP-1 ASO treated mice

From: Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice

 

Control ASO

DEP-1 ASO

P-value

LabMaster analysis

   

Food intake [g]

1.7 ± 0.2

2.0 ± 0.1

0.230

Water intake [ml]

1.8 ± 0.2

2.1 ± 0.2

0.317

Temperature [°C]

20.379 ± 0.015

20.520 ± 0.018

< 0.001

Locomotor activity [x + y]

61426 ± 5246

53600 ± 4465

0.287

Locomotor activity [z]

6296 ± 1095

4678 ± 770

0.217

Organ weight

   

[organ weight mg/body weight g]

Epididymal fat

18.4 ± 1.7

13.8 ± 1.0

0.038

Perirenal fat

7.3 ± 0.8

5.1 ± 0.6

0.048

Liver

38.6 ± 1.7

51.8 ± 0.9

< 0.001

Heart

4.8 ± 0.3

4.3 ± 0.1

0.197

Kidney

11.3 ± 0.9

11.1 ± 0.5

0.830

  1. Control ASO and DEP-1 ASO mice were characterized using metabolic cages (LabMaster) 4 weeks after ASO treatment. Measurements of an 18 hours period (12 am–6 am) are shown. Data were recorded every 15 min. After sacrificing of mice, organs weights were determined. Data are shown as mean ± standard error of the mean.
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Cell Communication and Signaling

ISSN: 1478-811X