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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Crystal structure of a cytocidal protein from lamprey and its mechanism of action in the selective killing of cancer cells

Fig. 6

Correlation between the SM-binding ability and cytotoxic activity of LIP. (a) BIAcore diagram and saturation curve of LIP bound to SM. LIP binds to SM with similar low affinity and slow kinetics. The KD values were calculated by BIAcore T200 analysis software (BIAevaluation version 3.0). (b) Dose-dependent effect of LIP on a liposome membrane composed of a mixture of PC and SM (PC:SM = 1:1). (c) The effect of LIP on a liposome membrane composed of a mixture of PC and SM depends on the SM content (PC:SM = 3:7, PC:SM = 7:3). Recombinant L-C1q proteins were used as a negative control in these experiments. (d) The content of sphingomyelin in different types of cells

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Cell Communication and Signaling

ISSN: 1478-811X