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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Elraglusib (formerly 9-ING-41) possesses potent anti-lymphoma properties which cannot be attributed to GSK3 inhibition

Fig. 1

Effect of various GSK3 inhibitors on lymphoma cell viability and PARP cleavage: HS-Sultan (A,D), Karpas-299 (B,E), and HH (C,F) cells were exposed to a panel of small molecule GSK3 inhibitors. Doxorubicin, an anthracycline chemotherapeutic, was used as a positive control. Cell viability assessments were performed using the MTS assay following a 72-h exposure to the compounds. PARP cleavage assays (marker of apoptosis) were performed on lysates generated after 24 h exposure to compounds. Quantification of PARP blots from 3 separate experiments is provided for HS-Sultan (G), Karpas-299 (H), and HH (I) cells

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Cell Communication and Signaling

ISSN: 1478-811X