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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: VSIG2 promotes malignant progression of pancreatic ductal adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation

Fig. 4

VSIG2 interacted with LAMTOR2 and mTOR. A AlphaFold Protein Structure Database (https://alphafold.ebi.ac.uk/) predicted the three-dimensional structure of VSIG2. B The results of VSIG2 mass spectrometry showed the possible interacting proteins, including LAMTOR2 and mTOR. C Proteins in VSIG2 mass spectrometry were analyzed from biological program, cellular condition and molecular function aspects by Gene Ontology (GO). D Kyoto Encyclopedia of Genes and Genomes (KEGG) predicted the related signaling pathway according to the results of VSIG2 mass spectrometry. E The interaction between VSIG2 and LAMTOR2 was testified by endogenic co-immunoprecipitation (Co-IP) in PANC-1 cells. F The interaction between VSIG2 and mTOR was verified by endogenic Co-IP assay in PANC-1 cells. G The interaction of VSIG2 with LAMTOR2 and mTOR and its spatial localization in PANC-1 cells were observed by immunofluorescence

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Cell Communication and Signaling

ISSN: 1478-811X