Fig. 1
From: Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Schematics of the writer, reader, eraser, and regulator for linear ubiquitination. Linear ubiquitin chains are assembled by the E3 ligase LUBAC along with the E2 UBE2L3. LUBAC comprises HOIP, HOIL-1, and SHARPIN, which serves as the linear ubiquitin writer. Several proteins decode linear ubiquitin by specifically binding to translate into a cellular effect (readers). Two deubiquitinases disassemble linear ubiquitin chains as the erasers. A20, TNF-inducible protein A20; CYLD, cylindromatosis; HOIL-1, heme-oxidized IRP2 ubiquitin ligase 1L; HOIP, HOIL-1-interacting protein; OTULIN, OTU domain-containing deubiquitinase with linear linkage specificity; SHARPIN, SHANK-associated RH domain-interacting protein; UBAN, ubiquitin-binding domain in ABIN proteins and NEMO; UBE2L3, ubiquitin-conjugating enzyme E2 L3. The figure was created with BioRender.com