Table 2 Applications of reconstructing apoptotic vesicles as carriers
From: Advances in biological functions and applications of apoptotic vesicles
Published year | Term | Parental cell | Size of vesicles | Induction method | Isolation method | Cargo | Function | Target cell | Animal | Applied method | Disease model | Ref. |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
2021 | Apoptotic bodies | Rat bone marrow neutrophils | 800-1200nm (Neu-ABs), 100-400nm (eNABs) | STS | Sequential centrifugation | HAL | Inflammation-tropism and immunoregulatory effects | Macrophages | Rats | Inject intravenously | Myocardial infarction | [72] |
2021 | Apoptotic bodies | External tumor cells | Approximately 950-1500nm | Nanoparticles loaded with anti-tumor drugs | Centrifugation | PR104A | Carry the remaining anti-tumor drugs to neighboring tumor cells | Internal tumor cells | Mice | Produced in vivo | Solid tumors | [30] |
2021 | Apoptotic bodies | B16F10 | <800nm | H2O2 after UV radiation | Sequential centrifugation | ASO | Cross blood-brain barrier | Microglial cells | Mice | Inject intravenously | Parkinson's disease | [16] |
2020 | Apoptotic bodies | Mouse T cells | 700-2000nm (ABs), 100-600nm (cABs) | STS | Sequential centrifugation | miR-21, curcumin | Target inflammatory regions and modulate inflammatory processes | Macrophages | Mice | Inject intravenously | Cutaneous inflammatory wound, colitis | [15] |
2020 | Apoptotic bodies | Mouse lymphoma cells | 1-5μm | UV radiation | Sequential centrifugation | AuNR-CpG | Target circulating monocytes | Monocytes (monocytes then infiltrate the tumor center) | Mice | Inject intravenously | Solid tumors | [83] |
2020 | Reconstructed apoptotic bodies (ReApoBds) | Cancer cells | 0.5 μm-10 μm (ApoBDs), 100-150nm (ReApoBds) | Serum starvation | Sequential centrifugation | Vancomycin | Target macrophages and cancer cells | Macrophages and cancer cells | Mice | Inject intravenously | Intracellular Staphylococcus aureus infection | [60] |