Table 3 Applications of constructing apoptotic vesicles as vaccines

2020

Apoptotic blebs

Macrophages J774A.1

The Apoptosis Inducer Kit

Animal experiment

Mice

Inject subcutaneously

Cutaneous leishmaniasis

N/A

N/A

[95]

2019

Apoptotic vesicles

Human melanoma cells

Bortezomib

Cell experiment

N/A

N/A

Malignant melanoma

N/A

N/A

[96]

2014

Apoptotic blebs

HL-60

Heat shock

Cell experiment

N/A

N/A

Myeloid leukemia

N/A

N/A

[97]

2014

Apoptotic blebs

HL-60

Heat shock

Cell experiment

N/A

N/A

Acute myeloid leukemia

N/A

N/A

[98]

2012

Apoptotic bodies

Chronic lymphocytic leukemia cells

Irradiation

Clinical trial

N/A

N/A

Chronic lymphocytic leukemia

52 weeks

15

[99]

2012

Apoptotic vesicles

Macrophages

Free of serum or BCG infection

Cell and animal experiment

Mice

Inject subcutaneously

Tuberculosis

N/A

N/A

[100]

2010

Apoptotic bodies

β cells

UVB irradiation

Cell and animal experiment

Mice

Inject intraperitoneally

Type 1 diabetes

N/A

N/A

[101]

2010

Apoptotic bodies

ARH77 myeloma cells

Irradiation

Cell experiment

N/A

N/A

Multiple myeloma

N/A

N/A

[102]

2009

Apoptotic bodies

Human melanoma cells

Dactinomycin

Clinical trial

N/A

N/A

Malignant melanoma

70 months

9

[103]

2006

Apoptotic vesicles

Macrophages

Free of serum

Cell and animal experiment

Mice

Inject subcutaneously

Tuberculosis

N/A

N/A

[35]

2005

Apoptotic bodies

Human leukemic B cells

Gamma ray

Clinical trial

N/A

N/A

B cell chronic lymphocytic leukemia

Exceed 23 months

9

[104]

2004

Apoptotic bodies

Chronic lymphocytic leukemia cells

Serum-free and four freeze–thaw cycles

Cell experiment

N/A

N/A

B cell chronic lymphocytic leukemia

N/A

N/A

[105]

2002

Apoptotic bodies

Melanoma cells

UVB irradiation, arginine butyrate or heat shock

Cell experiment

N/A

N/A

N/A

N/A

N/A

[106]

1997

Apoptotic bodies

Rat colon carcinoma cells

Sodium butyrate

Animal experiment

Rat

Inject subcutaneously or intraperitoneally

Colorectal cancer

N/A

N/A

[107]