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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Epigenetic meets metabolism: novel vulnerabilities to fight cancer

Fig. 1

The figure is representative of the mechanism that directs histones’ non-enzymatic modification. In cancer cells, high metabolic flux accounts for the overproduction of metabolites and waste products that under stress conditions can be activated in thioesters and react with histones tails in a non-enzymatic manner. These modifications might impair nucleosome architecture. Cancer cells counteract these conditions by overexpressing eraser enzymes. These erasers have a crucial role in cancer progression and might be precisely fought in a translational setting

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Cell Communication and Signaling

ISSN: 1478-811X