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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: Comparative immunological landscape between pre- and early-stage LUAD manifested as ground-glass nodules revealed by scRNA and scTCR integrated analysis

Fig. 9

Recluster and functional analysis of stromal cells. A Recluster of 2,577 endothelial cells, colored according to cell subclusters (Top). Heat map showed marker genes in each subclusters (Bottom). B Percentage of each subclusters in different groups. Error bars represent mean ± SEM. Colored dots represent different samples. Differences with p < 0.05 were indicated; two-sided unpaired Wilcoxon rank sum test was used for comparison. C Significantly enriched Hallmark pathways in tumor-associated endothelial cells isolated from nLung or AIS/IAC as determined by GSVA score (Left). Significantly enriched metabolism-related pathways in tumor-associated endothelial cells isolated from nLung or AIS/IAC as determined by GSVA score (Right). D Expression of glycose-metabolism related genes in different clusters of endothelial cells. E Recluster of 2,513 fibroblasts, colored according to cell subclusters (Left). Heat map showed marker genes in each subclusters (Right). F Kaplan–Meier overall survival curves of TCGA LUAD patients with the top 10 most differentially expressed genes between fibroblasts isolated from nLung and AIS/IAC. Abbreviation: AIS: Adenocarcinoma in situ; GSVA: Gene set variation analyses; IAC: Invasive adenocarcinoma; LUAD: Lung adenocarcinoma; SEM: Standard error of mean; TCGA: The Cancer Genome Atlas Program. * p < 0.05

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Cell Communication and Signaling

ISSN: 1478-811X