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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation

Fig. 2

FTV are identified in renal interstitium of DN patients and diabetic mice. A Immunostaining images of CD68 macrophages in the renal interstitium of DN patients and STZ mice. Scale bar: 10 μm. B1 TEM images of FTV-like nanoparticles (arrow) in the renal interstitium of DN patient, B2 as well as in STZ mice. (M: macrophages, IF: fibroblasts). Scale bar: 1 μm. C TEM images of FTV interact with renal fibroblast. Progressive Zooms into the TEM image reveal macrophage (M) scattered in close to fibroblasts (IF), characterized by the collagen fibers. FTV (triangle) and its internal vesicles (arrow) appear to have possibly been internalized by renal fibroblasts in DN patients. (PT: proximal renal tubule, TBM: basement membrane of renal tubules). Scale bar: 500 nm

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Cell Communication and Signaling

ISSN: 1478-811X