Biology Beyond Boundaries: Mitochondrial Insights, Computational Breakthroughs, and Clinical Transformations: International Conference Hosted by Savitribai Phule Pune University, Pune, India, January 29–31, 2024

Abstract

The Department of Biotechnology at Savitribai Phule Pune University organized an International Conference on Biology Beyond Boundaries: Mitochondrial Insights, Computational Breakthroughs, and Clinical Transformations. The symposium provided a highly interactive platform for sharing scientific ideas, cultural enrichment, and collaborations between scientists working across multidisciplinary areas including cell death and mitochondrial biology, computational approaches, and translational research to combat various human diseases. More than 250 delegates including international scientists, junior investigators, and students joined this exciting event. Several sessions were dedicated for junior investigators and graduate students to highlight scientific excellence as well as to gather scientific feedback in advancing their ongoing research. Although promising progress has been made in infectious diseases in India, noncommunicable diseases such as cancer, cardiac, and neurodegenerative diseases are increasing, leading to higher funding in these areas of research. The success of this meeting has provided a platform for future scientific conferences, which will foster collaborations between multidisciplinary areas of biological sciences to prevent and treat various human diseases in India, as well as further showcase the progress in Biomedical Sciences and Biotechnology throughout India.

Meeting Highlights

The International Conference on Biology Beyond Boundaries: Mitochondrial Insights, Computational Breakthroughs, and Clinical Transformations (https://events.unipune.ac.in/sites/Biotechnology/) was held between January 29–31, 2024, at the Savitribai Phule Pune University, Pune, India. This conference was organized by Prof. Rajesh Gacche, Savitribai Phule Pune University, Pune, India; Prof. Raymond B. Birge, Rutgers School of Biomedical and Health Sciences, USA; and Prof. Dhyan Chandra, Roswell Park Comprehensive Cancer Center, USA. This 3-day conference was highly successful and attracted more than 250 delegates, which include international scientists, Indian scientists, junior investigators, postdoctoral fellows, and graduate students. This conference provided unique platform for scientific exchange across many areas of basic and translation sciences and attracted more than 60 senior scientists from USA, Europe, and India. During 3-day meeting with two parallel sessions, 4 keynote talks, 11 plenary talks, 60 senior scientist talks were delivered in the diverse areas of biology and human diseases, such as cell death and mitochondrial biology, cancer and neudegenerative diseases, and other scientific areas involving diverse disease types. Various sessions were dedicated for platform presentations from young investigators, graduate students, and women in science. Additionally, more than 120 posters were presented focusing on diverse areas of multidisciplinary research in biological sciences. All the speakers and poster presentations are enumerated in the appendix in this meeting report.

Three major themes in the conference included (i) mitochondria, cell death, and human diseases, (ii) computational breakthrough and human disease management, and (iii) clinical research and transformations in health care. The inaugural ceremony on 29th January was addressed by the convenors of the conference: Prof. Rajesh Gacche, Savitribai Phule Pune University, Pune, India; and Prof. Dhyan Chandra, Roswell Park Comprehensive Cancer Center, USA. The opening ceremony was also addressed by Dr. Soumya Swaminathan, Chairman MS Swaminathan Foundation; Prof. Suresh Gosavi, Vice-Chancellor, Savitribai Phule Pune University, Pune; Dr. Cyrus Poonawala, Chairman and Managing Director, Serum Institutute of India; Dr. Adar Poonawala, CEO of Serum Institutute of India and Prof. Smita Zinjarde, Head, Department of Biotechnology, Savitribai Phule Pune University, Pune; and vote of thanks was delivered by Dr. Amul Sakharkar and Dr. Santosh Kathwate, Savitribai Phule Pune University, Pune, India.

Many scientific sessions highlighted basic and translational research focused on mitochondrial and cell death biology, cancer biology, neurodegenerative diseases, and many interdisciplinary areas of research related to vaccine development and various human disease outbreaks. The scientific sessions included four keynote lectures. Prof. Douglas W. Wallace, Director of the Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia, USA, summarized the current advances in mitochondrial medicine in the pandemic era by highlighting how mitochondrial bioenergetics has broad implications for both inherited and acquired diseases. Prof. Raymond B. Birge, Rutgers School of Biomedical and Health Sciences, Newark, New Jersey, discussed on how phosphatidylserine exposure, efferocytosis, and cell death pathways could be utilized for therapeutic intervention for various human diseases. Dr. Amel Karaa, Harvard Medical School, Massachusetts, USA, highlighted clinical updates on mitochondrial medicine. Prof. Stefan H.E. Kaufmann, Max Plank Institute for Infection Biology, Berlin, Germany, elaborated on basic research to clinical application to manage tuberculosis.

In this 3-day conference, many senior scientists discussed and exchanged their ongoing research related to mitochondrial biology, cell death biology, cancer, neurodegenerative diseases, vaccine development, communicable diseases, and disease outbreaks and pandemic management. Details of the senior scientists and abstracts of their talks are also presented in the following section, which contains titles of talks and affiliations of the authors. During the panel discussion, panel members led by Prof. Dhyan Chandra and Prof. Rajesh Gacche elaborated the current challenges in mitochondrial medicine and preparedness for disease outbreaks. The panel members also discussed the challenges faced by young investigators in advancing their scientific careers in academia and industries. Overall, the conference provided a platform for sharing scientific ideas across multidisciplinary fields by vibrant interactions among esteemed speakers and delegates as well as highlighting advances in mitochondrial biology and therapeutics in cancer, neurodegenrative diseases, communicable diseases, and other human diseases. The meeting was concluded by bestowing best oral and poster presentation awards to deserving young investigators and graduate students. In all, the meeting highlighted the rapid pace of biomedical research in India, opened new avenues of research and collaborations, and provided a culturally enriching experience for all.

Glimpses of the BBB-24 meeting: top panel, from left, (A) the inaugural function ceremony, (B) the panel discussion, (C-G) representative picture of prize and certificate distribution event, Miss Amruta Jadhav (C, oral presentation awardee), the representative picture of certificate and award distribution to the participants (D). Bottom panel from left, Dr. Ashwini Jadhav (E, oral presentation awardee under young investigators category), Dr. Sonali Kamble (F, poster presentation awardee), Mr. Navneendra Singh (G, oral presentation awardee), (H) the group photo during the meeting.

Titles and Affiliations of Speakers and Poster Presenters

Can Science solve Societal Challenges?

Dr. Soumya Swaminathan Chairman

MS Swaminathan Research Foundation, Chennai, India

Mitochondrial Medicine Clinical update: The landscape in 2024

Dr. Amel Karaa.

Division of Genetics Massachusetts General Hospital Harvard Medical School Boston, Massachusetts USA.

Whooping cough-from molecular mechanisms to vaccines

Prof. Peter Sebo

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic

Future Pandemic Preparedness

Dr. Umesh Shaligram

Executive Director, Serum Institute of India Pvt. Ltd, Pune, India

Multipronged epigenetic maneuvering by Mtb impacts host gene expression- an emerging strategy by the pathogen

Prof. V. Nagaraja

Professor of Microbiology, Indian Institute of Science, Bangalore, India

Role of Mitochondrial Exchange in Development of Chemotherapy Resistance in Cancer

Prof. Rana Pratap Singh

Professor of Cancer Biology, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

Therapeutic Potential of Osteopontin, a Chemokine like Protein in Breast and other Cancers

Prof. Gopal C. Kundu

Director R&D, KIIT University, Bhubaneswar, India

Translational research possibilities for mitochondrial disorders

Dr. Sagar Sen Gupta

Director, National Institute of Biomedical Genomics Kalyani, India

Copper-mediated metabolic reprogramming in breast cancer metastasis

Prof. Vivek Mittal.

Professor of Cell and Developmental Biology in Cardiothoracic Surgery, Weill Cornell Medical College, New York, USA.

COVID-19 Pandemic and strategies for future pandemic preparedness- a review of ICMR activities

Dr. Sheela Godbole.

Director, National AIDS Research Research Institute (NARI), Pune, India.

Microbiome based predictions, diagnosis and therapies for metabolic disorders

Prof. Yogesh Shouche.

Deputy Director, SKAN Reserach Trust, Bengaluru, India.

Plasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integrity

Dr. Puran Singh Sijwali.

Senior Principal Scientist, Centre for Cellular & Molecular Biology, Hyderabad, India.

Mitochondrial genetic variation and buparvaquone drug resistance in Theileria parasites

Dr. Dhanasekaran Shanmugam

Senior Principal Scientist, Biochemical Sciences Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, India.

Malaria Vaccines: Building on Success

Dr. Patrick Duffy.

Chief, Section Pathogenesis and Immunity, Division of Intramural Research, NIAID, NIH USA.

Translational Research in Academia: Malaria Vaccines as an Example

Prof. Sir Adrian Hill

Director of the Jenner Institute and Lakshmi Mittal and Family Professor of Vaccinology, University of Oxford, UK.

Advances in Nanoparticle Vaccines

Dr. Filip Dubovsky.

President, Research and Development, Novavax, Inc.

ML Models for Predicting Pre-Term Births

Prof. H. A. Nagarajaram.

Professor, Department of Systems and Computational Biology, School of Life Sciences, University of Hyderabad, Hyderabad, India.

Evaluating Circulating Tumor Cells (CTCs) in Cervical Cancer Using Omics Approach

Prof. Alokchandra Bharati.

Professor, Department of Zoology, University of Delhi, Delhi, India.

Neoantigens from non-canonical transcripts

Dr. Sharmila Bapat.

Scientist, National Center for Cell Science, Pune.

Regulation of ER-mitochondria contact sites and their functions by a nucleoporin

Dr. Jomon Joseph.

National Centre for Cell Science, Ganeshkhind, Pune-411007, Maharashtra State, INDIA.

REM Sleep protects the brain from neurodegeneration

Dr. Birendra Nath Mallick.

Professor, Director & Head of the AINN, AUUP.

RePORT India: Advancing insights for combatting tuberculosis

Dr. Amita Gupta.

Chief, Division of Infectious Diseases, Johns Hopkins School of Medicine.

RSV Vaccine Development: A Precedent for Structure-based Antigen Design:

Prof. Barney Graham.

Professor of Medicine and Microbiology, Biochemistry, & Immunology.

Role of the Laboratory in Human Papillomavirus (HPV) Public Health and Research

Dr. Elizbeth Unger.

Chief, Chronic Viral Disease Branch, CDC, GA, USA.

Assembly of respiratory complexes control via import

Dr. Swasti Raychaudhuri.

CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad-500007, India and Academy of Scienti.c and Innovative Research (AcSIR), Ghaziabad- 201,002, India.

Polarization of Cancer stem cell markers during Epithelial to Mesenchymal Transition in Oral Squamous Cell Carcinoma

Tajindra Singh Saluja, Dharmendra Kumar, Satyendra Kumar Singh.

Stem Cell/ Cell Culture Lab, Centre for Advance Research, King George`s Medical University, Lucknow, UP.

SERS Emerging as a Rapid Detection Tool for Biological Specimens.

Prof. Balaprasad Ankamwar.

Department of Chemistry, Savitribai Phule Pune university.

The mitochondrial UPR, mitochondrial disease and aging

Prof. Ramesh Bhonde.

Scientist Emeritus, Dr D.Y. Patil Vidyapeeth (DPU).

LINC00324/miR-493-5p/MAPK1 axis promotes metastasis of esophageal squamous cell carcinoma

Dr. Aklank Jain.

Department of Zoology Central University of Punjab, Bathinda, India.

Mitochondrial Medicine in the pandemic era

Prof. Douglas Wallace.

Perelman School of Medicine, University of Pennsylvania, USA.

The Calcium Code: Unveiling Mitochondrial Calcium Regulation.

Dr. Dhanendra Tomar.

Department of Internal Medicine, Wake Forest University Winston-Salem, USA.

Mitochondria in intestinal stem cell homeostasis and repair

Dr. Subhrajit Saha.

University of Kansas Medical Center.

Modeling new disease-causing pathogenic variants from rare disease in the mitochondrial and peroxisomal fission factor DNM1L in Drosophila melanogaster

Dr. Michael Wangler.

Molecular and Human Genetics, Baylor College of Medicine Houston, Texas, USA.

Effect of environmental chemicals on skin and ocular inflammatory diseases: Computational biology applications to identify mechanisms and interventions.

Dr. Neera Tewari-Singh.

Michigan State University, USA.

Multi-nucleated cells use ROS to induce breast cancer chemoresistance in vitro and in vivo

Dr. Mahitosh Mandal

Indian Institute of Technology, Kharagpur, India.

The mitochondrial UPR, mitochondrial disease and aging

Prof. Cole Haynes.

UMass Chan Medical School, Worcester, MA, USA.

Mitochondrial genetics and the susceptibility to post-partum breast cancer

Prof. Doris Germain.

Icahn School of Medicine, Mount Sinai, New York, USA.

Mitochondria as Epigenetic Regulators of Aging

Prof. Keshav Singh.

The University of Alabama at Birmingham, USA.

Oncogenic BRAF Activates the ATF5-Dependent Mitochondrial Unfolded Protein Response to Dynamically Control Mitochondrial Function and Senescence in Early Disease

Prof. Jerry Edward Chipuk.

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, USA.

The mitochondrial unfolded protein response in prostate cancer

Prof. Dhyan Chandra.

Roswell Park Comprehensive Cancer Center Bu.alo, New York, United States.

Mitochondrial Calcium Nexus: Unmasking Alzheimer's Molecular Enigma

Dr. Pooja Jadiya.

School of Medicine, West Forest University Winston-Salem, USA.

Unwinding the LOVE-HATE relationship between FBXO31 and γH2AX in DNA damage response: Implication in cancer chemotherapeutics

Dr. Manas Santra.

National Centre for Cell Science, Ganeshkhind, Pune-411007, Maharashtra State, INDIA.

Role of mitochondrial quality control in stemness and therapeutic resistance of glioblastoma

Dr. Lokendra Sharma.

Associate Professor Department of Molecular Medicine & Biotechnology, Sanjay Gandhi Post Graduate Institute of Medical Science (SGPGIMS) Rae Bareli Road, Lucknow (U.P.)-226,014.

Tuberculosis: From Basic Research to Clinical Application

Prof. Stefan H. E. Kaufmann.

Founding Director, Max Plank Institute for Infection Biology, Berlin, Germany.

Gold-Nanoheater-Mediated Targeting of Powerhouse in Cancer for Next-Generation Chemo-Photothermal Therapy

Dr. Sudipta Basu.

Associate Professor, Department of Chemistry, IIT Gandhinagar.

Harnessing therapeutic vulnerability in prostate cancer phenotype via anoikis.

Dr. Natasha Kyprianou.

Icahn School of Medicine, Mount Sinai, New York, USA.

3 Decades of Biology Beyond Boundaries: Pune’s Contribution to Global Infectious Diseases Research

Prof. Robert Bollinger.

Professor of Medicine, Public Health and Nursing, Johns Hopkins University.

Role of nuclear lamins in regulating chromosomal stability in cancer cells

Prof. Kundan Sengupta.

Indian Institute of Science Education and Research (IISER), Pune.

Phosphatidylserine exposure and efferocytosis: Harnessing cell death pathways for therapeutic intervention.

Prof. Raymond Birge.

Rutgers School of Biomedical and Health Sciences, Newark, New Jersey USA.

Bringing affordable, accessible, and acceptable cures for HIV and sickle cell disease to all parts of the world

Prof. Mike McCune.

Professor Emeritus of Medicine, University of California, San Francisco.

Scientific and Clinical Development of Monoclonal Antibodies to Prevent Malaria

Dr. Robert A. Seder.

Chief, Cellular Immunology Section, Vaccine Research Center, NIAID, NIH, USA.

VPM1002-a novel tuberculosis vaccine

Dr. Leander Grode.

Managing Director,Serum Life Science Europe, GmbH, Germany.

Exploring mitochondrial diseases: a multifaceted approach

Prof. K. Thangaraj.

Director, Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India.

Metabolic Detours in Bladder Cancer: Biological and Therapeutic Implications

Dr. Nagireddy Putluri.

Baylor College of Medicine, Houston, Texas United States.

Exploring mitochondrial diseases: a multifaceted approach

Dr. Richa Rikhy.

Indian Institute of Science Education and Research, Dr. Homi Bhabha Road,

Pune 411,008, India.

A BID-MTCH2 love story: Energizing mitochondria until apoptosis do them part?

Prof. Atan Gross.

Weizmann Institute of Science, ISRAEL.

Translocation of HSP47 and generation of mitochondrial reactive oxygen species in human neuroblastoma SK-N-SH cells following electron and X-ray irradiation

Prof. Hideyuki J. Majima.

School of Allied Health Sciences, Walailak University, Thasara, Thailand.

Oral Talks

Post-translation regulation of PUMA: Importance in cancer therapeutics

Sharad S. Tat¹, Akshita Upreti^2*, Rajesh N. Gacche¹, Manas K. Santra.³

1. Department of Biotechnology, Savitribai Phule Pune University, Pune.

2. BITS Pilani, KK Birla Goa Campus.

3. National Centre for Cell Science, Ganeshkhind, Pune-411007, Maharashtra State, INDIA.

Email: p20200002@goa.bits-pilani.ac.in.

Sirtuin 6 promotes tumor survival by modulating DNA repair pathway and AKT signaling via PHLPP1 in ovarian cancer

Amarnath Karna¹, Manoj Kumar², Pallavi Agarwal.¹

1. Amity Institute of Molecular Medicine and Stem Cell Research, Amity University Uttar Pradesh, Sector 125, Noida 201313, India

2. Amity Institute of Genome Engineering, Amity University Uttar Pradesh, Sector 125, Noida 201313, India

Email: amarnathkarna@gmail.com; Pagarwal6@amity.edu.

Gene inactivation via truncation mutation and Helicobacter pylori pathoadaptation

Ankita Das, Anamika Ghosh, Riya Saha, Debabani Ganguly, Sujay Chattopadhyay

Centre for Health Science and Technology, JIS Institute of Advanced Studies and Research

Kolkata, JIS University, West Bengal, India.

Email: ankitadas0901@gmail.com.

Deciphering the interaction of the N-terminal domain and mitochondrial targeting domain of AnkZF1 and Finding out the minimal domain responsible for its mitochondrial localization during stress

Bhoopesh Maheswaran, Mudassar Ali, and Koyeli Mapa

Protein Homeostasis Laboratory, Department of Life Sciences, School of Natural Sciences,

Shiv Nadar University, Greater Noida, Uttar Pradesh

Email: bm850@snu.edu.in.

Dynamics of Inflammatory MicroRNAs in HIV-1 Infection of Macrophage: Potential

Mechanisms and Therapeutic Targets

Harshithkumar R¹, Mollina Kaul², Anupam Mukherjee.¹

1. Division of Virology, ICMR-National AIDS Research Institute.

2. School of Biosciences, Apeejay Stya University.

Email: amukherjee@nariindia.org.

Tailoring scaffold stiffness for epigenetic reconditiong of hepatocarcinomacellsu

Kaizar J. Bharmal, Joyita Sarkar.

Institute of Chemical Technology.

Email: j.sarkar@marj.ictmumbai.edu.in.

PSMD9 Chaperone Modulates Mitochondrial Endoplasmic Reticulum Contact Site and

Mitochondrial Fission

C. Merlyn Anthony^1,2, Joel Christie^1,2, Prasanna Venkatraman^1,2*

Advanced Centre for Treatment Research & Education in Cancer (ACTREC), Tata Memorial

Centre, Kharghar, 410,210, Navi Mumbai, India.

Homi Bhabha National Institute, BARC Training School Complex, Anushaktinagar, 400,094,

Mumbai, India.

Email: camerlyn@gmail.com.

N-acetyl glucosamine modified Boltorn H40 nanoconstructs for pH-sensitive delivery of anti-cancer drugs to cancer tissues

Aazam Shaikh^1,2, Rajesh Salve^1,2, Devyani Sengar ^1,2, Virendra Gajbhiye ^1,2

1. Nanobioscience group, Agharkar Research Institute, Pune-411004, India.

2. Savitribai Phule Pune University, Pune-411004, India.

Email: aazamshaikh@aripune.org.

Evaluation of Antiproliferative and Anti-inflammatory potential of isolated Labdane diterpenoids from Andrographis paniculata (Burm. f.) Wall. ex Nees: an important medicinal plant prescribed in Ayurveda

Rafik U. Shaikh¹, Nabila M. Shaikh², Rohan J. Meshram³, Rajesh N. Gacche.⁴

1. Department of Botany, Poona College, Camp, Pune -411 001 (MS), India.

2. Department of Botany, Tuljaram Chaturchand College, Baramati, Pune-413102(MS), India.

3. Bioinformatics Centre, Savitribai Phule Pune University, Pune -411 007 (MS), India.

4. Department of Biotechnology, Savitribai Phule Pune University, Pune -411 007 (MS), India.

Email: rafikbot@gmail.com.

Silibinin inhibits cell viability, migration, invasion, and tumor growth of head and neck cancer

Navneendra Singh^1,2, Mansoor Ali², Aishwarya Jaiswal², Deepali Mishra², Rana Zaidi¹* and Rana P. Singh^2,3,4*

Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New

Delhi, India.

2. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

3. Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi, India.

4. Skaggs School of Pharmacy and Pharmaceutical Sciences, AMC Campus, University of.

Colorado, Aurora, CO, USA.

Email: navneendra@gmail.com.

Mfn2 plays a significant role in glucose e metabolism and mitochondrial energy homeostasis: A proteomics and metabolomics approach

Prakash G Kulkarni¹, Soumya Sahoo³, Vaibhavi M Mohire², Jeetender Chugh³,

Tanushree Banerjee¹ and Amul J Sakharkar¹*.

1. Department of Biotechnology, Savitribai Phule Pune University, Pune, India 411,007.

2. Molecular Neuroscience Research Centre, Dr. D.Y. Patil Biotechnology and Bioinformatics.

Institute, Tathawade, Pune, India 411,033.

Indian Institute of Science Education and Research, Pune, India 411,008.

Email: amul.sakharkar@unipune.ac.in.

The inhibition of eIF2a kinase HRI as a Key Player in Breast Cancer Sensitization

Prithvi Kulkarni¹, Ritu Agrawal¹, Pratishtha Mankar¹, Anirban Majumder¹,

Abhijeet Singh¹, Ganesh Suraj Bose¹, Abhijeet Kulkarni², Jayanta K Pal³, Samit Chattopadhyay⁴, Smriti Mittal¹*

1. Department of Biotechnology, Savitribai Phule Pune University, Pune 411,007.

2. Bioinformatics Centre, Savitribai Phule Pune University, Pune 411,007.

3. Dr. D.Y. Patil Biotechnology and Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth,

Tathawade, Pune 411,033.

BITS Pilani K K Birla Goa Campus, Goa 403,726

Email: prithvikulkarni65@gmail.com.

Design of Selective Inhibitors for eIF2-alpha kinases, Translation Controllers of Global Protein Synthesis

Rama Kulkarni¹, Saurabh Palrecha¹, Sonal Talekar¹, Soumyadeep Mangal², Ganesh.

Bose², J. K. Pal³, Smriti Mittal², Abhijeet Kulkarni¹, Manali Joshi.¹

1. Bioinformatics Centre, Savitribai Phule Pune University, Pune India.

2. Department of Biotechnology, Savitribai Phule Pune University, Pune India.

3. Dr. D. Y. Patil Biotechnology & Bioinformatics Institute, Pune India.

Email: ramaskulkarni19@gmail.com.

Induction of Mitochondrial Dysregulation and Anoikis in Metastatic Cancer Cells by Phytosynthesized Plasmonic Nanoparticles

Snehal Patil¹, Atul Bharde¹, Mrunal Ratnaparkhi.²

1. Department of Microbiology, Savitribai Phule Pune University, Pune, Maharashtra, India.

2. OneCell Diagnostics, Pune, Maharashtra, India.

Email: universeluvzsnehal@gmail.com.

FBXW9 inhibits breast cancer pathogenesis by targeting Cell cycle regulatory proteins

Snigdha Samanta, and Manas Kumar Santra.

Cancer Biology Division, National Centre for Cell Science, Ganeshkhind Road, Pune,

Maharashtra 411,007, India.

Email: Snigdha.subrata@gmail.com or snigdha.s@nccs.res.in.

Understanding the role of Clathrin light chains in regulating mitochondrial function during early development

Surabhi Sharma, Mahak Tiwari, Deepa Subramanyam,

National Centre for Cell Science, Ganeshkhind Road, Pune, Maharashtra 411,007, India.

Email: sharma.surabhi94@gmail.com.

Isatin as an Inhibitor of Candida albicans Biofilm formation: An in vitro study

Ashwini Khanderao Jadhav*, Sayali Ashok Chaugule, Sankunny Mohan Karuppayil.

Department of Stem Cell and Regenerative Medicine, Medical Biotechnology, Centre for.

Interdisciplinary Research, DY Patil Education Society (Deemed to be University),

Kolhapur, Kasaba Bawada, Maharashtra, India. 416,006.

Email: ashujadhav09@gmail.com.

Quantum Dot Based Fluorescent Biosensing Device for early screening and detection of cancer biomarkers

Arpita Pandey Tiwari*, Pranoti Kamble, C.D Lokhande, Yogendra Kumar Mishra.

1. Centre for Interdisciplinary Research, D.Y. Patil Education Society, (Deemed to be University), Kolhapur.

2. Mads Clausen Institute, Smart Materials Laboratory University of Southern Denmark, Sønderborg, Denmark.

Email: arpitaptiwari@gmail.com.

Nanotherapeutic strategies to improved brain uptake of Bacoside A attenuated behavioral symptoms in scopolamine-induced Alzheimer disease in Wistar rats

Dr. Vaishali Undale.

Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tumaram Nagar,

Pimpri, Pune 411,018.

Email: vaishali.undale@dypvp.edu.in.

Structural and functional characterization of a novel chimeric transcript RMND5AANAPC1

Amruta Jadhav and Sharmila A. Bapat.

National Centre for Cell Science, Ganeshkhind Road, Pune, Maharashtra 411,007, India.

Email: amrutaj355@gmail.com.

Epigenetic inactivation of MECOM targets KRAS/ERK/EGR1 proliferation pathway in ovarian cancer

Ibha Singh¹, Manoj Kumar², Pallavi Agarwal.¹

1. Amity Institute of Molecular Medicine and Stem Cell Research, Amity University

Uttar Pradesh, Sector 125, Noida 201,313, India

2. Amity Institute of Genome Engineering, Amity University Uttar Pradesh, Sector 125, Noida, 201,313, India

Email: ibhasingh07@gmail.com.

Exploring the Relation between Circulatory miRNAs and Mitochondrial Partners by Deciphering Interaction Patterns in the Metastasis of Breast Cancer

Akshita Saravanan, Palak Bafna, Vishal Kumar Sahu, Subhayan Sur, Amit Ranjan, Soumya Basu*

Cancer and Translational Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Tathawade, Pune -411,033, India.

Email: soumya.basu@dpu.edu.in.

Impact of SARS-CoV-2 infection on the function of pancreatic ß-cells: unraveling the molecular connections.

Aman Soni, Triveni Sodnawar, and Shilpy Sharma.

Department of Biotechnology, Savitribai Phule Pune University, India.

Email: soniaman939@gmail.com.

In-silico approaches in aptamers design and their impact on emerging technologies in computational biology

Amrita Sinharay and Anup Kale*

Department of Biosciences and Technology, Dr. Vishwanath Karad MIT-World.

Peace University, Pune – 411,038, India.

Email: anup.kale@mitwpu.edu.in.

Inter-clonal co-evolution of E. coli core genes potentially linked to uropathogenicity

Anamika Ghosh Ankita Das, Debabani Ganguly, and Sujay Chattopadhyay.

Centre for Health Science and Technology, JIS Institute of Advanced Studies and Research, Kolkata, JIS University, West Bengal, India.

Email: anamikaghosh2809@gmail.com.

Breaking Barriers: Advancements in HIV Viral Load Monitoring for Enhanced Accessibility in India

Anisha Bhamare, Dhanashree Jadhav, Madhuri Chandane Tak, and Anupam Mukherjee*

Vellore Institute of Technology, Vellore.

Email: anishabhamare5113@gmail.com.

Understanding the role of ANKZF1 and ANKZF1–VCP interaction during mitochondrial proteotoxic stress

Anjali and Koyeli Mapa*

Department of life science, School of natural sciences, Shiv Nadar University, Greater.

Noida, Uttar Pradesh.

Email: an114@snu.edu.in, Koyeli.mapa@snu.edu.in.

Unveiling the Therapeutic Targets of Selected Flavonoids from Argyreia nervosa (Burm. f.) Bojer in Type-2 Diabetes Mellitus (T2DM): Insights from Network Pharmacology and Molecular Docking Studies

Anuja D. Kamble and Anjali A. Kulkarni*

Department of Botany, Savitribai Phule Pune University, Ganeshkhind Road, Pune 411,007, Maharashtra, India.

Email: anjali.uop@gmail.com or akulkarni@unipune.ac.in.

Carbon quantum dots-DNA nanocomplex for non-viral gene delivery and bioimaging applications

Anuja A Vibhute and Arpita Pandey Tiwari*

Center for Interdisciplinary, D. Y. Patil Education Society, (deemed to be University), Kolhapur.

Email: anujavibhute06@gmail.com.

Assessment of Thyroid Function Test in Vitiligo

Apurva Patil¹, Parineeta Samant², and Shylaja Someshwar.³

1. Ph.D. Scholar, Department of Biochemistry, MGM Institute of Health Sciences, Navi Mumbai, India.

2. Professor, Department of Biochemistry, MGM Medical College, Navi Mumbai, India.

3. HOD & Professor, Department of Dermatology, MGM Medical College, Navi Mumbai, India.

Email: apurvap.tech@gmail.com.

Molecular docking and simulation studies of Morinda citrifolia phytocompounds against CagA Oncogenic protein of Helicobacter pylori

Arghyadeep Bhattacharjee^1,2, Sayan Poddar³, Oindrilla Mukherjee¹*

1. Department of Biotechnology, National Institute of Technology, Durgapur-713209, West Bengal, India.

2. Department of Microbiology, Kingston College of Science, Beruanpukuria, Barasat, Kolkata-700120, West Bengal, India.

3. Department of Biosciences & Biomedical Engineering, IIT Indore Khandwa Rd, Simrol, Madhya Pradesh 453,552.

Email: arghyadeep55@gmail.com.

Cell-free Circulatory Mitochondrial DNA as a Potential Biomarker in Human Stress: A Meta-Analysis Across Psychological and Physiological Stress Conditions

Arpan Chattopadhyay, and Hemanth Naick B*

Dept of Sports Biosciences, Central University of Rajasthan.

Email: 2021phdsbs001@curaj.ac.in.

Human Islet Amyloid Polypeptide and its role in inducing insulin resistance in the skeletal muscles

Arya Raju Naik, Shreyada N. Save, and Shilpy Sharma*

Department of Biotechnology, Savitribai Phule Pune University, Ganeshkhind Road, Pune 411,007.

Email: naikarya2001@gmail.com.

Diatoms in Diagnostics (DID): Utilization of the nanoporous frustules for sensing and detection

Chintan Bhatt, Bhushan Devkule, Neha Ninave, Ashish Pawar, Madhu Choubey, and Anup Kale*

Department of Biosciences and Technology, Dr. Vishwanath Karad MIT-World Peace University, Pune – 411,038, India.

Email: anup.kale@mitwpu.edu.in.

Exploring the Therapeutic Potential of MicroRNAs Modulating Inflammation to restrict HSV-2 Infection

Debashree Dass, Vaishnavi Sonawane, Dr. Anupam Mukherjee, Anwesha Banerjee,

ICMR-National AIDS Research Institute, Pune.

Email: debashree650@gmail.com.

Deciphering the interplay between ß-catenin and ceramide signaling in colorectal cancer.

Deepak Thombre, Rituparna Panigrahi, Kaustubh Nadkarni, and Vivek Vaish*

Department of Biotechnology, Savitribai Phule Pune University, Ganeshkhind, Pune-411007, Maharashtra, INDIA.

Email: rujuta.thombre@gmail.com.

In-Silico Identification of Potential Quadruplex Forming Sequences in LncRNAs of Cervical Cancer

Deepshikha Singh, Dr. Bhaskar Datta, Dr. Nakshi Desai, and Viraj Shah.

Indian Institute of Technology, Gandhinagar.

Email: deepshikhasingh1899@gmail.com.

Fermentative production of amylase using fungal cultures: Aspergillus awamori and Aspergillus oryzae.

Devidas Matre¹, Poornima Kumbhar¹, Priti Kamble²*, and Mahendra Ranjekar.

1. Sinhgad college of science Pune.

2. Technical Director, Green Vital Biotech, Pune.

Email: devidasmatre7332@gmail.com.

Breaking Barriers: Anticancer activity of doxorubicin-loaded bilosomes

Devyani Sengar, Vandana Menaria, Virendra Gajbhiye.

Agharkar Research Institute, Pune.

Email: devyanisengar@aripune.org.

Comparative assessment of selected phytoextracts with promise in healthcare transformation for wound management

Gajanan Sonawane, and Smita Zinjarde,

Department of Biotechnology, Savitribai Phule Pune University, Pune.

Email: gsonawane764@gmail.com.

Microgravity impairs mitochondrial membrane potential in cardiomyocytes

Gita Hare¹, R. N. Gacche², Maulesh Gadani³, Anindita Chakraborty⁴, Amol Jadhav⁵, Megha Mishra¹, and Varsha Wankhade¹*

1. Department of Zoology, Savitribai Phule Pune University, Pune 411,007.

2. Department of Biotechnology, Savitribai Phule Pune University, Pune 411,007.

3. ISRO SAC, Ahmadabad -380,015.

4. UGC-DAE Consortium forScientific Research, Kolkata -700,106, India.

5. Nirav Biosolution, Aundh, Pune-411007.

Email: varsha2w@rediffmail.com.

Antimicrobial and anticancer potential of plant defensin peptides

Javed A. Mulla, Srushti Bhagwat, and Vaijayanti A. Tamhane*

Department of Biotechnology, Savitribai Phule Pune University, Pune, Maharashtra 411,007.

Email: mulla.javed7@gmail.com.

Exploring antimicrobial activity of surfactin and their interactions against CDKs and RTKs as an anticancer agent: An In-silico method

Priyanka S. Dhotare¹, Nasir R. Shaikh², and Kailas D. Sonawane.³

1. Division1 Department of Microbiology Shivaji University, Kolhapur.

2. Department of Microbiology, Yashwantrao Chavan collage of Science Karad.

3. Department of Biochemistry, Shivaji University, Kolhapur.

Email: psd.rs.microbio@unishivaji.ac.in / priya.dhotare18@gmail.com.

Unraveling the mechanism of RNA Binding Proteins mediated regulation of Chimeric Transcripts.

Yash Kuber

National Centre for Cell Science, Ganeshkhind, Pune-411007, Maharashtra State, INDIA

Email: kuberyash21@gmail.com.

Precision Autism Spectrum Disorder Prediction through Machine Learning: A Comprehensive Framework for Enhanced Early Detection and Personalized Intervention

Rujuta Thombre, Viveka Patil, Dr. Sanket Bapat*

School of Bioengineering Sciences and Research, MIT ADT University, Pune, India

Email: rujuta.thombre@gmail.com.

Apoptosis induced by Chloroxylon swietenia (Roxb.) DC through down-regulation of the NF-B pathway in human breast cancer MCF-7 cells.

Sonali S. Kamble and Vivek N. Dhabadge

School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded-431 606 (MS), India

Email: kamblesonali3189@gmail.com.

Dietary Omega 3 fatty acids can reverse mitochondrial dysfunction in synovial macrophages integral to osteoarthritis

Vanshika Srivastava, and A. Harsulkar

Department of Pharmaceutical Biotechnology, Poona college of Pharmacy, BVDU, Pune, 411038

Email: srivansh2408@gmail.com.

Formulation and Evaluation of 3D printed tablet by using the Fused Deposition Modelling Technique

Vaishali P. Shelke, S. L. Patwekar, and Vishal A. Pagare

Swami Ramanand Teerth Marathwada University

Email: vpshelke808@gmail.com.

ACY-1215, an isozyme-specific HDAC6 inhibitor, suppresses hypoxia-induced PI3K/AKT/STAT3/c-MYC signalling and attenuates metastasis in breast cancer

Urmi Bagchi¹, Rupesh Dash², Sonia Kapoor¹*

1. Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Uttar Pradesh, Sector 125, Noida 201,313, India

2. Institute of Life Sciences, Nalco Square, Bhubaneswar-751023, India

Email: urmi.bagchi13@gmail.com.

Gold oligonucleotide nanoconstructs based electrochemical biosensor for detection of SARS-CoV-2 RNA

Tejaswini Patil, Arpita Pandey Tiwari,

Department of Medical Biotechnology and Stem cell and Regenerative Medicine, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be university),

Kolhapur-416006, Maharashtra, India

Email: patiltejaswini1010@gmail.com, arpitaptiwari@gmail.com.

The Role of Mitochondrial Dynamics in Angiogenesis

Kalpana T, and Sanjay Kumar

Indian Institute of Science Education and Research (IISER), Tirupati

Email: Kalpanatankay@students.iisertirupati.ac.in.

Use of natural compounds as adjuvants with therapeutic drugs against colorectal cancer: A combinatorial regimen to curb chemoresistance and dose related side effects.

Kaustubh Nadkarni, Deepak Thombre, Mallar Banerjee, Sanjana Sarkar, and Vivek Vaish*

Department of Biotechnology, Savitribai Phule Pune University, Ganeshkhind, Pune 411,007, Maharashtra, INDIA

Email: knadkarni@yahoo.in.

Identifying effective phytomolecules targeting multi-drug efflux pumps of Pseudomonas aeruginosa and Enterobacter cloacae

Kawaljeet Kaur, Sagar Reddy, Pramod Barathe, Varsha Shriram, Sanjay Kharat, and Vinay Kumar,

Biotechnology Department, Modern College Ganeshkhind, Pune 411,007.

Email: kawaljeetkaur157@gmail.com.

Anaerobic growth and drug susceptibility of versatile fungal pathogen Scedosporium apiospermum.

Krishna K Yadav, Yogesh Nimonkar, Stefan J Green, Sahabram Dewala, Manikprabhu N Dhanorkar, Rohit Sharma, Vinay R Rale, and Om Prakash,

SIT BuilSymbiosis International (Deemed University), Maharashtra 412,115

Email: yadavkrishna9881@gmail.com.

FRET based nano-biosensor for detection of Neonatal Jaundice

Mahima Tiwari, Enosh Gaikwad, Aditi Jeena, Madhu Choubey, Abhay Mahindre, and Anup Kale*

Department of Biosciences and Technology, Dr. Vishwanath Karad MIT-World

Peace University, Pune 411,038, India.

Email: anup.kale@mitwpu.edu.in.

Unveiling the Symphony of Circulatory microRNAs in Accelerated Liver Fibrosis during HIV-HCV Co-infection

Madhuri Chandane-Tak and Anupam Mukherjee

Division of Virology, ICMR-National AIDS Research Institute, Pune, India

Email: amukherjee@nariindia.org.

Deciphering the feeback signaling between Akt and p53 in colorectal cancer cell lines.

Masrat Shaikh, Deepak Thombre, Pujarini Giri, Kaustubh Nadkarni, and Vivek Vaish*

Department of Biotechnology, Savitribai Phule Pune University, Ganeshkhind, Pune-411007, Maharashtra, INDIA

Email: masratshaikh0599@gmail.com.

Microplastics in Indian landfills: An emerging pollutant and health hazard

Meenakshi Verma, Pooja Singh, and Manikprabhu Dhanorkar

Symbiosis International (Deemed University), Pune

Email: meenakshi.verma@scwrm.siu.edu.in.

Assessing the impact of urbanization and altered lifestyles on the epidemiological landscape of cardiovascular diseases: A study in Pune population

Megha Mishra, Rajesh Gacche, Varsha Wankhade, Gita Hare, C.B. Chavan, and Anindita Chakraborty

Savitribai Phule Pune University, Pune

Email: gonu.megha@gmail.com.

Reversal of induced morphogenesis in Candida albicans by Mephentermine

Ravikumar B. Shinde¹, Mukta M. Bamankar², Mamta K. Maind² and Santosh H. Kathwate²*

1. Department of Zoology, Shri Pundlik Maharaj Mahavidyalaya, Nandura, Buldhana 443,404

2. Department of Biotechnology, Savitribai Phule Pune University, Pune 411 007

Email: muktabamankar@gmail.com.

Aptamer tethered hetero-polymer conjugated mesoporous silica nanoparticles (MSNPs) mediated delivery of dual siRNA to induce apoptosis in breast cancer cells

Niladri Haldar, Virendra Gajbhiye*

Nanobioscience, Agharkar Research Institute, Pune-411038, India

Email: niladrihaldar@aripune.org.

Syzygium cumini (L.) Skeels alleviates glycation-induced diabetic nephropathy by targeting mitochondrial dysfunction and ER stress

Nilima S. Bangar, and Rashmi S. Tupe*

Symbiosis School of Biological Sciences (SSBS), Symbiosis International (Deemed University) (SIU), Lavale, Pune-412115, Maharashtra, India

Email: nilima.bangar@ssbs.edu.in.

Efficient genome-wide off-target classification in the CRISPR/Cpf1 system

Pragya Kesarwani^1,2, and Durai Sundar^2,3

1. Regional Centre for Biotechnology, Faridabad, Haryana 121,001, India

2. Department of Biochemical Engineering and Biotechnology, IIT Delhi, Hauz Khas, New Delhi 110,016, India

3. Yardi School of Artificial Intelligence, IIT Delhi, Hauz Khas, New Delhi 110,016, India

Email: pragya.kesarwani@rcb.res.in.

Mfn2 plays a significant role in glucose metabolism and mitochondrial energy homeostasis: A proteomics and metabolomics approach

Prakash G Kulkarni¹, Soumya Sahoo³, Vaibhavi M Mohire², Jeetender.

Chugh³, Tanushree Banerjee² and Amul J Sakharkar ¹*.

1. Department of Biotechnology, Savitribai Phule Pune University, Pune, India 411,007.

2. Molecular Neuroscience Research Centre, Dr. D.Y. Patil Biotechnology and Bioinformatics Institute, Tathawade, Pune, India 411033.

3. Indian Institute of Science Education and Research, Pune, India 411,008.

Email: amul.sakharkar@unipune.ac.in.

Early cancer detection by using fluorescent carbon quantum dots probe

Pranoti Kamble, and Arpita Pandey Tiwaria*

Department of Stem cell and Regenerative medicine and Medical biotechnology, Centre for interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University),

Kolhapur-416006, Maharashtra, India.

Email: pranotikamble0@gmail.com.

Effect of a Snake Venom Peptide, NN-32 Generates Cellular Toxicity in Lung Cancer Cells A549.

Ms. Pratibha Kurkute, and Sangeeta V. Pandit

Department of Zoology, Savitribai Phule Pune University

Email: pratibha.kurkute95@gmail.com.

Investigation of biofilm formation and Extracellular Polymeric Substances production in bacteria isolated from wound infection

Prabhavati Shinde¹, Shraddha Jaiswal², Vidya Tale³*

Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth (Deemed to be University) Pune Maharashtra India 411,045

Email: prabhavati.shinde.ext@bharatividyapeeth.edu.

Lopinavir in combination with ritonavir facilitates antileishmanial response by lipid accumulation and mitochondrial dysfunction

Priyanka Mazire and Amit Roy*

Department of Biotechnology, Savitribai Phule Pune University, (Formerly University of Pune) Ganeshkhind Road, Pune-411007 Maharashtra, INDIA

Email: amitathens@gmail.com.

PPARgamma agonists as adjuvants to curb dose-dependent side-effects in colorectal cancer.

Rachna Vidhate*, Deepak Thombre, Sanjana Sarkar, Mallar Banerjee, Vivek Vaish

Department of Biotechnology, Savitribai Phule Pune University, Ganeshkhind, Pune-411007, Maharashtra, INDIA

Email: rachnarvidhate@gmail.com.

Dynamics of Chemotherapy-Induced Dormancy in Breast Cancer Spheroids

Rahul Gawarguru, Sukanya Gayan, Tuli Dey.

Department of Biotechnology, Savitribai Phule Pune University, Pune, MH, India

Email: ra.gawarguru@gmail.com.

Nucleolin aptamer targeted co-delivery of anticancer drug and siRNA via multifunctional MSNPs to overcome drug resistance in TNBC

Rajesh Salve, Pramod kumar, Virendra Gajbhiye

Agharkar Research institute, G.G. Agarkar road, Shivaji nagar, Pune

Email: rsalve@aripune.org.

Aptamer-Tethered Hyperbranched Bis-Mpa Polyester Dendrimers For Targeted Delivery Of Sirna And Gene Silencing In Breast Cancer Cells

Rajkumar Samanta, Niladri Haldar, Rajesh Salve, Virendra Gajbhiye*

Nanobioscience, Agharkar Research Institute, Pune-411038, India

Email: rajkumarsamanta@aripune.org.

Methicillin Resistant Staphylococcus species from Pune Region

Litake GM¹*, Bankhele Rajnigandha¹, Desai Suvarna² Bankhele R.

1. Department of Biotechnology, PES s Modern College, Ganeshkhind, Pune-411016

2. Department of Biotechnology, PES s Modern College, Shivajinagar, Pune-411005

Email: gmlitake@gmail.com.

Development of a Human-Relevant in vitro platform to assess Tumor-stromal interaction and immunotherapeutics

Ranjani N. Iyer, Abhishek Teli, Tuli Dey *

Department of Biotechnology, Savitribai Phule Pune University

Email: rannies.iyer5@gmail.com.

Elucidating the role of lysine-33 linked ubiquitinated protein in cell cycle progression

Rumpa Mahata

Lab No 12, NCCS Complex, S.P. Pune University Campus, Pune 411,007

Email: rumpamahata001@gmail.com.

Evaluating the Therapeutic Potential of Extracellular Vesicles Derived from Adiantum capillus-veneris and Moringa

Saee Chavan, Rutuja Rupnawar, Amruta Naigaonkar and Kalpana Chandramore

Vidya Pratishthan s Arts, Science and Commerce College, Baramati. Rajiv Gandhi

Email: saeechavan5288@gmail.com.

In-Silico analyses of Sequence variability in the rdrpcomplex components ofavian influenza viruses

Samarpan Bhattacharjee¹, Pratip Shil¹, Payel Ghosh², Jayati Mullick¹*

1. CMR-National Institute of Virology, Pashan, Pune-411021,

2. Bioinformatics Centre, SavitribaiPhule Pune University,Pune-411007.

Email: jayati_mullick@hotmail.com.

Understanding the modulatory role of ATAD1 during mitochondrial proteotoxic stress in mammalian cells

Sarbani Bhattacharjee¹ and Koyeli Mapa¹*

Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Greater

Noida, Uttar Pradesh

Email: sb390@snu.edu.in.

Selected non-antifungal drugs inhibit planktonic growth and germ tube formation in Candida albicans.

Mamta Krushnarao Maind and Santosh H Kathwate*

Department of Biotechnology, Savitribai Phule Pune University, Pune, India 411 007.

Email: mkmaind@gmail.com, santoshkathwate@gmail.com.

In vitro and In Silico Analysis of antimalarial drugs towards ergosterol synthesis in Candida albicans.

Sargun Basrani, Sayali Chougule, S.Mohan Karuppayil,AshwiniK. Jadhav*

D.Y. Patil education society, Kolhapur

Email: pg21780@gmail.com.

Roberts syndrome cause differential expression of mitochondrial genes

Sayali Marathe, Snehal Ahire and Tania Bose

Department of Biotechnology, Savitribai Phule Pune University, Pune, Maharashtra, India

Email: tania.bose@gmail.com.

Butyl isothiocyanate as an inhibitor of growth and virulence factors of Candida albicans

Shivani Balasaheb Patil, Prof. Dr. S. Mohan Karuppayil,

Dr. Y. Patil Education Society (Deemed to be University), Kolhapur

Email: patilshivani007@gmail.com

Evaluation of biofilm production, structure and antibiotic susceptibility in Staphylococcus saprophyticus from contact lens.

Shraddha Jaiswal, Prabhavati Shinde, Nishita Jain, and Vidya Tale*

Department of Microbial Biotechnology, Rajiv Gandhi Institute of IT and Biotechnology.

Email: shraddha.jaiswal-rgitbt@bvp.edu.in.

NSAAdb: A Comprehensive Database of Non-Standard Amino Acids

Shraddha Ranpise and Vijay B. Baladhye

Bioinformatics Centre, Savitribai Phule Pune University, Pune-411 007 (MS), INDIA.

Email: vijaybaladhye@gmail.com.

Lipid-protein interactions contributes to sequence evolution in membrane arm subunits of respiratory complexes

Pooja Gupta^1,2, Sristi Chakroborty¹, Arun Rathod^2,3, Shreya¹, Suparna Ghosh^1,2,

Pallavi Rao T^1,2, R Nagaraj^1,2, Moutusi Manna^2,3 and Swasti Raychaudhuri^1,2*

1. CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad-500007, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

3. CSIR Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar 364,002, Gujarat, India.

Email: sristi@ccmb.res.in.

Chimeric CanDef peptides with modified structure–function having enhanced inhibition of pathogenic fungi

Srushti Bhagwat¹, Javed Mulla¹, Manali Joshi², Vaijayanti Tamhane¹*

1. Department of Biotechnology, IBB building, SPPU, Pune

2. Department of Bioinformatics, SPPU, Pune

Email: srushtibhagwat1998@gmail.com.

Investigating bioactive compounds from medicinal plants as inhibitors for epoxide hydrolase, a target for inflammation.

Shweta Kumari, Ameeta Ravikumar

Department of Biotechnology, IBB building, Savitribai Phule Pune University.

Email: shweta.jaynagar@gmail.com.

Potential biomarker for early detection of SARS-CoV2

Snehal Bhumkar, Manjari Jonnalgadda, Prof. Suresh Gosavi, Dr. Richa ashma,

Department of Zoology, Savitribai Phule Pune University.

Email: snehal.bhumkar21@gmail.com.

Chloroxylon swietenia (Roxb.) DC Demonstrate Multi-Targeted Anti-Tumorigenic Potential Against Glioblastoma Multiforme: Promising Resource for Adjuvant Therapy

Snehal Dawkhar, Upasana Kapoor, Navnath Kumbhar, Pallavi Shewale,

Ramakrishna Nimma, Rajesh Gacche*

Department of Biotechnology, Savitribai Phule Pune University, Pune-7.

Email: dawkhar.sd@gmail.com.

Proteome modulations induced by Oroxylum indicum metabolites manifest into apoptosis and migrastasis in cancer cells

Advait Agashe, Supriya Acharya, Vedangi Hyatnagarkar, Javed Mulla, Vitthal T.

Barvkar, Tuli Dey, Vaijayanti Tamhane*

1. Department of Biotechnology, Savitribai Phule Pune University, Ganeshkhind Road, Pune 411,007, Maharashtra, India.

2. Department of Botany, Savitribai Phule Pune University, Ganeshkhind Road, Pune

411,007, Maharashtra, India.

Email: Jaishidhdham31@gmail.com.

Role of MicroRNA-140 in Hepatitis E Virus Replication

Pooja Salunke¹, Rajashree Patil¹, Yogesh A Karpe.²

1. Agharkar Research Institute, Nanobioscience Group, G. G. Agarkar Road, Pune 411,004, India; Savitribai Phule Pune University, Ganeshkhind, Pune 411 007, India.

2. Agharkar Research Institute, Nanobioscience Group, G. G. Agarkar Road, Pune 411,004, India; Savitribai Phule Pune University, Ganeshkhind, Pune 411 007, India.

Email: poojasalunke@aripune.org.

Understanding the functional and structural relationship of Malto-oligosaccharide forming amylase from novel Streptomyces strain and their application in food and pharma industry

Vidhya Shinde, V. Koteswara Rao*

CSIR-National Chemical Laboratory, Pune, Maharashtra, India.

Email: vk.shinde@ncl.res.in.

Functional Relevance of Chimeric Transcripts in Ovarian Cancer

S.A. Bapat, and Sushmita Sahoo

National Centre for Cell Science, Ganeshkhind, Pune-411007, Maharashtra State, INDIA

Email: sushmitasahoo64@gmail.com.

Determination of L -DOPA content in Selected Mucuna Species from India: Promising Interventions for Parkinson's Disease.

Sagar Shinde, E. A. Singh¹* and Archana Sharbidre.²

1. Department of Plant Biotechnology, Bharati Vidyapeeth (Deemed to be University) Rajiv Gandhi Institute of Information technology and Biotechnology, Pune411043, Maharashtra, India.

2. Department of Zoology, Savitribai Phaule Pune University, Pune-411007, Maharashtra India.

Email: elangbam.singh@bharthividyapeeth.edu, sagarshinde951@gmail.com.

Unravelling the therapeutic landscape of Biochanin A: Deciphering mRNA and miRNAtargeted networks in Glioblastoma for identifying promising therapeutic targets

Pallavi Shewale, Rajesh Gacche*

Department of Biotechnology, Savitribai Phule Pune University, Pune, Maharashtra, India

Email: rngacche@unipune.ac.in.

In healthcare research, "omics" are useful instruments for precision medicine and illness diagnostics.

Udaybhanu.P.Sirdeshmukh

Department of Biotechnology, Rajarshi Shahu Mahavidyalaya (Autonomous), Latur,

Maharashtra, India.

Email: uday1biotech@gmail.com.

Electrochemical sensor for detection of dengue virus NS1 protein

Aishwarya Kapse

D. Y. Patil University, Kolhapur-416006

Email: aishkapse1996@gmail.com.

Elucidating the role of altered mitochondrial dynamics in mitochondrial biogenesis and its involvement in ovarian cancer

Manita Raina.

Indian Institute of Science and Education and Research, Tirupati, Andrapradesh, India.

Email: manitaraina@students.iisertirupati.ac.in.

Effect of Lopinavir in combination with Ritonavir in mitochondria-mediated cell death process of unicellular protozoan parasite Leishmania donovani

Amit Roy.

Department of Biotechnology Savitrbai Phule Pune University Ganeshkhind.

Road, Pune-411007, Maharashtra, India

Email: amitathens@gmail.com.

Profile of Antiangiogenic, anticancer and antioxidant activity of Tylophora indica and yathocline purpure

Dhole N. A., Kodam K. M.

1. Digambarrao Bindu Arts, Commerce & Science College, Tamsa road, Bhokar431801.

2. Division of Biochemistry, Department of Chemistry, Savitribai Phule Pune.

University, Pune-411007.

Email: nageshdhole2019@gmail.com.

Exploring the potential of fish bacterial communities in gluten hydrolysis

Snehal Gagare¹, Vinay Kumar¹ Sanjay Kharat

1. Department of Biotechnology, Modern College of Arts Science and Commerce Ganeshkhind, Pune, Maharashtra, India

2. Department of Zoology, Modern College of Arts Science and Commerce Ganeshkhind, Pune, Maharashtra, India

Email: snehalgagare7@gmail.com.

In Vitro Antitubercular, antioxidant and cytotoxicity activities of Ficus religiosa fruits Silver Nanoparticles and its synergism with DOT s drugs: a comparative study.

Rahul A. More

Department of Microbiology, Dayanand Science College, Latur-413512 (MS), India

Email: rahulakmore@gmail.com.

Characterization of green and chemically synthesized Yitrium oxide nanoparicles.

Dr. Archna Sahay.

E 804, MSR Olive, Datta Nagar, Katraj, Pune-411046.

Email: sahayarchna@gmail.com.

Liposome based formulation containing, Mucuna Pruriens, Withania somnifera, Sida cordifolia, Glycyrrhiza glabra, and Centella asiatica, to cross blood brain barrier as a remedy for Parkinson s disease.

Rajesh Jagdish Sharma, Yashashree Nitin Tilekar

Department of Biotechnology, Vidya Pratishthan's Arts, Science & Commerce College, Baramati, Pune, Maharashtra, India

Email: rajesh_vpascc@yahoo.com.

Arbuscular Mycorrhizal Fungi in Capparis zeylanica plants of Maharashtra, India

Prakash. P. Sarwade and Kavita N. Gaisamudre (Sarwade).

1. Shikshan Maharshi Guruvarya R. G. Shinde Mahavidyalaya, Paranda Dist.Osmanabad. Pin Code. 413 502, (M.S.) India.

2. Shriman Bhausaheb Zadbuke Mahavidyalaya Barshi Tal. Barshi, Dist-Solapur 413,401. (M.S.), India.

Email: ppsarwade@gmail.com.

Exploring the Therapeutic potential of Azadirachta indica andEucalyptus globulu sextracts against Atopobium vaginae in Bacterial vaginosis Management: A Comprehensive Research Investigation.

Dr. Pratima Wagh

Maratha Vidya Prasarak Samaj's K.T.H.M.College. Nashik, Maharashtra, India

Email: pratima.p.wagh@gmail.com.

Enhancing the screening of cervical cancer by HPV RTPCR testing of stained smears of cervical swab

Charusheela R Gore¹, Hemant G Deshpande², Chandrashekhar G Raut³, Vaishali Bhatt³, Manasi V Chavan³, Prachi V Prasad³, Avinash A Lendave³, Wrunda C Raut¹, Anjali H Deshpande¹, Anand J Nagarkar¹, Jitendra S Bhawalkar.⁴

Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pimpri, Pune,

MS, India. (Departments: 1- Pathology, 2- Obstetrics & Gynecology,

3-Interdisciplinary Research, 4- Community Medicine).

Email: directoridr.dypmc@dpu.edu.in.

Characterization of green and chemically synthesized yattrium oxide nanoparticles

Archana Pukale, Archna Sahay and Shamim Shaikh

Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth, Deemed to be University, Katraj, Pune.

Email: archna.sahay@bharatividyapeeth.edu.

Development of Tool to automate process of stable multi-epitope vaccine candidate construction against EBV

Akshata Ekbote¹, Payel Ghosh², Swapnil C. Kamble^1*

1. Department of Technology, Savitribai Phule Pune University, Ganeshkhind, Pune-411007

2. Bioinformatics Centre, Savitribai Phule Pune University, Ganeshkhind, Pune-411007

Email: sckamble@unipune.ac.in.

Screening of halophilic bacteria for probiotic properties

Hrishikesh Mungi, Archana Pundle, and Swapnil Kamble*

Department of Technology, Savitribai Phule Pune University, Ganeshkhind, Pune-411007

Email: sckamble@unipune.ac.in.

Identification of molecular players maintaining the stemness in ovarian cancer

Aravindan Narayanan, Sharmila A. Bapat*

National Centre for Cell Science, Ganeshkhind, Pune-411007

Email: sabapat@nccs.res.in.