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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Transcriptional responses to direct and indirect TGFB1 stimulation in cancerous and noncancerous mammary epithelial cells

Fig. 4

Time trends in the expression of genes related to cell cycle progression in MCF10A and MCF7 cells. Examples of (a) transcriptional regulators, (b) cyclins, (c) cyclin-dependent kinases and (d) their inhibitors, (e) cell division cycle proteins, (f) cell division cycle associated proteins, (g) DNA polymerases, (h) proteins involved in chromosomal replication, (i) proteins involved in DNA repair and (j) markers of proliferation. The cells were treated according to the scheme shown in Figure S2a. TGF, direct TGFB1 treatment; CM, conditioned medium treatment. *** padj < 0.0001, ** padj < 0.001, * padj < 0.05 (significance of differences was marked for the entire run if the adjusted p value vs. Ctr reached a given value at least at one experimental point). See also Figures S6 (cell cycle in KEGG pathways) and S7 (time trends of other cell cycle-related genes)

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Cell Communication and Signaling

ISSN: 1478-811X