Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content
Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Transcriptional responses to direct and indirect TGFB1 stimulation in cancerous and noncancerous mammary epithelial cells

Fig. 5

Inhibition of estrogen signaling and induction of cell death after TGFB1 treatment in MCF7 cells. Time trends in the expression of genes related to estrogen signaling and apoptosis in MCF10A and MCF7 cells: (a) steroid receptors and EGFR; (c) ESR1 targets; (d) prosurvival genes; (e) proapoptotic genes. The cells were treated according to the scheme shown in Figure S2a. TGF, direct TGFB1 treatment; CM, conditioned medium treatment. *** padj < 0.0001, ** padj < 0.001, * padj < 0.05 (significance of differences was marked for the entire run if the adjusted p value vs. Ctr reached a given value at least at one experimental point). (b) Response of MCF7 and MCF10A cells to TGFB1 treatment analyzed by Western blot. The cells were treated according to the scheme shown in Figure S2a. The levels of the indicated proteins were analyzed in total protein extracts. ACTB was used as a loading control

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X