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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Deubiquitinase USP5 regulates RIPK1 driven pyroptosis in response to myocardial ischemic reperfusion injury

Fig. 7

Schematic model in which the USP5 deficiency inhibits MI/R-induced pyroptosis by suppressing RIPK1-mediated activation of caspase-8. Upon I/R, USP5 expression is upregulated, which subsequently inhibits K63-linked polyubiquitination of RIPK1 and promotes caspase-8 cleavage of gasdermin D to elicit pyroptosis. When USP5 is downregulated or mutated, RIPK1 reverse K63-linked deubiquitination, which leads to RIPK1 autophgic degradation and inhibits cell pyroptosis

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Cell Communication and Signaling

ISSN: 1478-811X