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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Dose-dependent role of AMH and AMHR2 signaling in male differentiation and regulation of sex determination in Spotted knifejaw (Oplegnathus punctatus) with X1X1X2X2/X1X2Y chromosome system

Fig. 7

Reconstruction the sex determination regulatory pathway involving amhr2. A The dosage compensation effect of amhr2 in male and female gonads. Amh secreted by Spotted knifejaw germ cells binds to amhr2 on supporting cell membranes, driving sex differentiation. In males, amhr2y on the Y chromosome promotes the synthesis of multiple receptor variants (amhr2ay, amhr2by, amhr2cy), while females synthesize only amhr2a from the X chromosome. Dosage compensation effect highlights the role of amhr2 in promoting male sex differentiation. B Sex determination regulatory pathway of Spotted knifejaw. The amh/amhr2 system is positioned upstream in the Sex determining pathway. In male, amhr2 has three mRNA transcripts (amhr2ay, amhr2by, amhr2cy), while females have one (amhr2a). Amhr2 expression in male testes significantly boosts male-associated gene expression (sox9b, dmrt1), enhancing testosterone synthesis and promoting male sex differentiation. Similarly, Amhr2 expression in females boosts female-associated gene expression (wnt4, foxl2), leading to estrogen synthesis and facilitating female sex differentiation

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Cell Communication and Signaling

ISSN: 1478-811X