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Table 2 Clinical characteristics of the IQUB842del patient’s wife with ICSI

From: IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice

Subject

Proband’ wife

Age (years)

33

Length of primary infertility history (years)

3

Body mass index (BMI)

25.68

FSH (mIU/mL)

2.18

LH (mIU/mL)

0.68

E2 (pg/mL)

13.2

PRL (ng/mL)

9.74

Prog (ng/ml)

< 0.1

AMH (ng/ml)

6.56

Protocol

Short-acting GnRH-agonist long protocol

E2 level on the trigger day (pg/ml)

3314.85

No. of follicles ≥ 14 mm on the trigger day

11

No. of follicles ≥ 18 mm on the trigger day

7

No. of oocytes retrieved

15

No. of MII oocytes (%)

14/15 (93.3)

No. of 2 PN (%)

12/14 (85.7)

No. of cleaved embryos (%)

12/12 (100)

No. of usable embryos (%)

4/12 (33.3)

No. of blastocysts (%)

-

No. of frozen embryos

4

Transfer cycles

1 (FET)

Transferred embryos

2

No. of gestational sacs (%)

2

No. of clinical pregnancies (%)

2

No. of newborns (%)

2

  1. GnRH, gonadotrophin-releasing hormone. MII, Metaphase II-arrested. PN, pronucleus. FET, frozen-thawed embryo transfer