Fig. 4

Mechanism of glycolysis inhibition & DNA damage in tumor therapy. DDR: DNA damage repair; ROS: reactive oxygen species. The combination of glycolysis inhibitors and DNA damaging agents constitutes a highly persuasive therapeutic approach, with their synergistic effects potentially attributed to the following mechanisms: 1) diminishing the efficacy of DDR; 2) elevating intracellular ROS levels; 3) modifying epigenetic patterns; 4) overcoming drug resistance by disrupting survival pathways; 5) resisting cellular senescence mechanisms that promote survival; and 6) enhancing the immune system's capabilities