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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signaling

Fig. 5

Transcriptomic profile of EC during activation/inactivation of Notch. (A) Schematic illustration of the experimental design to study the transcriptomic profile of EC during activation/inactivation of Notch. (B) Principal component analysis (PCA), showing the multidimensional differences between EC overexpressing the intracellular domain of NICD1 and NICD3, and EC with inactivated NOTCH1 and NOTCH3 relative to control EC transduced by shGFP. (C) The heatmap of the top differentially expressed gene (DEGs) by RNA seq in EC. The control is EC, transduced by shGFP, the target gene of which is not expressed in EC. (D) The heatmap of the DEGs whose expression increased in the EC group with activated intracellular domains NICD1 and NICD3, and decreased in the EC group transduced with shRNA targeting NOTCH1 and NOTCH3

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Cell Communication and Signaling

ISSN: 1478-811X