Fig. 4
From: From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders
Pathogenic narratives of liver-related diseases in ferroptosis. Ferroptosis is implicated in range of liver diseases, including non-alcoholic fatty liver disease, metabolic dysfunction-associated steatotic liver disease, alcoholic liver disease, Ischemia reperfusion injury and so on. Abbreviations: 4-HNE, 4-hydroxynonenal; MDA, malondialdehyde; VLDL, very Low Density Lipoprotein; Lip-1, liproxstatin-1; Fer-1, ferrostatin-1; α-KG, α-Ketoglutaric acid; CISD1, CDGSH iron-sulfur domain-containing protein 1; IDO1, indoleamine 2,3-dioxygenase 1; RNS, reactive nitrogen species; ART, artemether; HSC, hematopoietic stem cell; HO-1, heme oxygenase-1; HMGB1, high mobility group box 1; ACSL4, acyl-coenzyme synthetase long-chain family member 4; HH, hemochromatosis; HCC, hepatocellular carcinoma; DILI, drug-induced liver injury; ALF, acute liver failure