Fig. 8

Mevalonate pathway inhibition regulates SS-induced YAP1 nuclear translocation. (A) Quantification of SREBP2 n/c ratio in cells exposed to 24 h SS with or without presence of LOVA 1 µM. (B) Quantification of YAP1 n/c ratio in cells exposed to 24 h SS with or without presence of LOVA 1 µM. Representative images show SREBP2 depicted in magenta, YAP1 depicted in blue, and actin depicted in white. All experiments were performed in at least 3 independent biological replicates. Statistical significance calculated with t-test and shown as * p < 0.05, ** p < 0.01, *** p < 0.001 between LOVA treatment and solvent control