Table 1 Clinical trials using AR agonists or antagonists in patients with impaired muscle function or sarcopenia. DHEA: dehydroepiandrosterone; 11KA4: 11-Ketoandrostenedione; TRT: testosterone replacement therapy; ADT: androgen deprivation therapy; PC: prostate cancer
Intervention/treatment | Study name | Condition/disease | Development stage | Study number |
|---|---|---|---|---|
Androgen replacement | Pathogenesis of Sarcopenia and Metabolic Changes in Aging | Sarcopenia | Completed | NCT00254371 |
AndroGel (Testosterone gel), Anastozole (Aromatase Inhibitor) | Effect of Aromatase Inhibition Versus testosterone in older Men with low testosterone: randomized-controlled trial | Hypogonadism, Diabetes, Sarcopenia, Osteoporosis, depression | Completed | NCT00104572 |
DHEA, 11KA4 | DIMOXIS | Insulin resistance, Endocrine System Disease | Recruiting | NCT05263557 |
ADT | Investigation bone and skeletal muscle interaction in man with prostate cancer | PC | Completed | NCT03386812 |
Testosterone Undecanoate + exercise training | Does human skeletal muscle possess an epigenetic memory of testosterone? | Healthy Aging, Age-related Sacopenia, Testosterone Deficiency | Phase II/III | NCT05964920 |
Testosterone enanthate | A study to evaluate a skeletal-muscle microbiopsy technique with dynamic proteomic measurement in healthy male volunteers | Cachexia | Completed | NCT01962454 |
Testosterone enanthate/ Finasteride | Testosterone plus Finasteride treatment after spinal cord injury | Spinal cord injury, Trauma, Nervus system, Wound and injures, Gonadal Disorders, Endocrine System Disease, Hypogonadism, Genital disease (Male) | Completed | NCT02248701 |
AndroGel (Testosterone gel) | The Testosterone Trial in Older Men | Andropause | Completed | NCT00799617 |
Testosterone gel | TOM: Testosterone in Older Men with Sarcopenia | Sarcopenia, Hypogonadism, Muscular Diseases | Terminated | NCT00240981 |
AndroGel (Testosterone gel) | A Study to Evaluate the Effect of TRT on the Incidence of Adverse Cardiovascular Events (MAGE) and Efficacy Measures in Hypogonadal Men (TRAVERSE) | Cardiovascular disease, Hypogonadism | Completed | NCT03518034 |
MK-0773 | A phase IIA randomized, placebo- controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK- 0773 in female partecipants with sarcopenia | Sarcopenia | Completed | NCT00529659 |