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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: The ester derivative Palmitoylcarnitine abrogates cervical cancer cell survival by enhancing lipotoxicity and mitochondrial dysfunction

Fig. 6

PC affects the expression of mitochondrial biogenesis genes and induces mitophagy in CC. A Representative agarose gel image of semiquantitative RT-PCR depicting the expression of PGC1α, TFB1M, COX2, NRF1, MFN1, MFN2 and SIRT3 in control and PC-exposed SiHa and HeLa cells. ACTB was used as a loading control (NC – Negative control). B Representative Western blot images showing the expression of PGC1α, TFAM, COX2, MFN1, and SIRT3 in PC-treated SiHa and HeLa cells. C and D Representative Western blot images and bar graphs of CPT1 A and PDK3 expression in control and PC-exposed SiHa and HeLa cells. E and F Representative Western blot images and bar graph showing the expression of CPT1 A, COX2, BECN1, LC3B I, and LC3B II in mitochondria isolated from control and PC-exposed SiHa and HeLa cells, respectively. *P < 0.05, **P < 0.01, and ***P < 0.001 indicates statistical significance

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Cell Communication and Signaling

ISSN: 1478-811X